Vector-Borne and Zoonotic Diseases
Comparison of Post-Lyme Borreliosis Symptoms in Erythema Migrans Patients
with Positive and Negative Borrelia burgdorferi Sensu Lato Skin Culture
____________________________________
To cite this article:
Da¹a Stupica, Lara Lusa, Tja¹a Cerar, Eva Ru¾iæ-Sabljiæ, Franc Strle.
Vector-Borne and Zoonotic Diseases. -Not available-, ahead of print.
doi:10.1089/vbz.2010.0018.
Online Ahead of Print: November 17, 2010
Da¹a Stupica,1
Lara Lusa,2
Tja¹a Cerar,3
Eva Ru¾iæ-Sabljiæ,3 and
Franc Strle1
1Department of Infectious Diseases, University Medical Center Ljubljana,
Ljubljana, Slovenia.
2Faculty of Medicine, Institute for Biostatistics and Medical Informatics,
Ljubljana, Slovenia.
3Faculty of Medicine, Institute of Microbiology and Immunology, University
of Ljubljana, Ljubljana, Slovenia.
Address correspondence to:
Da¹a Stupica
Department of Infectious Diseases
University Medical Center Ljubljana
Japljeva 2, Ljubljana 1525
Slovenia
E-mail: _cerar.dasa@gmail.com_ (mailto:cerar.dasa@gmail.com)
Abstract
Purpose: Limited data exist on differences of erythema migrans patients
with either positive or negative Borrelia burgdorferi sensu lato skin
culture.
Methods: We analyzed 252 adult patients with erythema migrans in whom skin
biopsy specimen was cultured for the presence of B. burgdorferi sensu
lato. Evaluations of epidemiological, clinical, and microbiological findings
were conducted at baseline, 14 days, 2, 6, and 12 months after treatment with
either doxycycline or cefuroxime axetil.
Results: One hundred fifty-one (59.9%) patients had positive skin culture
(86.9% B. afzelii, 8.0% B. garinii, 5.1% B. burgdorferi sensu stricto) and
101 (40.1%) had negative skin culture. Patients in the culture-positive and
culture-negative groups were comparable for the basic demographic,
epidemiological, clinical, and laboratory characteristics at presentation.
Statistically significantly worse selected treatment outcome parameters in the
culture-positive group compared with the culture-negative group were
established during follow-up. Treatment failure was documented in two patients who
were culture positive and in none in the culture-negative group.
Conclusions: Although findings for the pretreatment characteristics were
comparable between the erythema migrans skin culture-positive and
culture-negative patients, some parameters indicate that borrelia skin culture
positivity may predict a less-favorable treatment outcome.
_http://www.liebertonline.com/doi/abs/10.1089/vbz.2010.0018_
(http://www.liebertonline.com/doi/abs/10.1089/vbz.2010.0018)
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