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Wednesday, November 9, 2011

[AlternativeAnswers] Sugar and the Inflammation Connection


Good Morning!

Sugar and Inflammation

One of the reasons inflammation occurs is from a rapid rise in blood sugar,
which causes biochemical changes in the cell. Staying away from sugar and
high-glycemic (simple) carbohydrates, which the body rapidly converts to sugar,
is one of the best ways to decrease inflammation. C-reactive protein (CRP) is a
key factor of inflammation. In a major study, published in the New England
Journal of Medicine, people with elevated CRP levels were four and one-half
times more likely to have a heart attack. Not only is elevated CRP more accurate
than cholesterol in predicting heart attack risk, but high CRP levels have
turned up in people with diabetes and pre-diabetes and in people who are
overweight. [58, 59,61]

When blood sugar goes up rapidly, sugar can attach itself to collagen in a
process called "glycosylation," or the Browning Reaction, increasing inflexible
and inflammation. CRP is not found in foods. However, its levels in the body are
strongly influenced by diet.

A recent study by Simin Liu, M.D., Ph.D., of the Harvard Medical School found
that women who ate large amounts of high-glycemic (or diabetes promoting)
carbohydrates, including potatoes, breakfast cereals, white bread, muffins, and
white rice, had very high CRP levels. Women who ate a lot of these foods and
were also overweight had the highest and most dangerous CRP levels. [62].

The body makes CRP from interleukin-6 (IL-6), a powerful inflammatory chemical.
IL-6 is a key cell communication molecule, and it tells the body's immune system
to go into asperity, releasing CRP and many other inflammation-causing
substances. Being overwieght increases inflammation because adipose cells,
particularly those around the midsection, make large amounts of IL-6 and CRP. As
blood sugar levels increase, so do IL-6 and CRP. Both overweight and high blood
sugar levels increase the risk of heart disease, very likely because of the
undercurrent of inflammation. [61].

The best way to deal with cravings is to very carefully control blood sugar and
insulin by staying away from the simple carbohydrates and eating more protein.
In a few days, blood sugar will stabilize and cravings will go away. Good
(complexed) carbohydrates, which are low on the glycemic index include: apples,
apsaragus, beans, broccoli, blackberries, blueberries, cabbage, cantaloupe,
citrus fruits, green beans, honeydew melon, kiwi, leafy greens, peaches, pears,
plums, raspberries, spinach, strawberries.

Bad (simple) carbohydrates, which are high on the glycemic index include:
bananas, breads, carrots, cereals processed with added sugar, corn, French
fries, French toast, fruit juices, mangos, pancakes, papaya, pasta, peas,
popcorn, white potatoes, white rice, sugar, waffles.

Dietary fats also influence inflammation. Most omega-6 fats, found in margarine
and corn and safflower oils, are the basic building blocks of arachidonic acid
and prostaglandin E2, two of several key inflammation-causing substances in the
body. In contrast, omega-3 fats, found in fish, fish oils, and vegetables, have
an inflammation-suppressing effect. [63]

Gamma-linolenic acid (GLA) is an omega-6 fat that enhances the anti-inflammatory
effect of omega-3 fats. Both GLA and omega-3 fish oils have been found helpful
in arthritis and other inflammatory disorders. [64,65] GLA is found in leafy
green vegetables and dietary supplements. Similarly, oleic acid, an omega-9 fat
found in olive oil, walnut oil, sunflower oil, soybean oil, canola oil,
avocados, nut butters and macadamia nuts have anti-inflammatory properties.

Good sources of protein include: Fish such as sardines, salmon, cod, haddock,
halibut, snapper and tuna. Meat and poultry include: turkey, chicken with no
skin, occasional lean beef, lean pork and lean ham. Soy products are also a
great source of protein. Also included are egg whites, low fat cottage cheese,
milk and yogurt.

Andrew Pacholyk, MS, L.Ac
Therapies for healing
mind, body, spirit


58. Ridker PM, Hennekens CH, Buring JE, et al. C-reactive protein and
other markers of inflammation in the prediction of cardiovascular
disease in women. New England Journal of Medicine, 2000;342:836-843.

59. Pradhan AD, Manson JE, Rifai N, et al. C-reactive protein,
interleukin-6, and risk of developing type 2 diabetes mellitus. JAMA,

60. Festa A, D'Agostino R, Howard G, et al. Chronic subclinical
inflammation as part of the insulin resistance syndrome. The insulin
resistance atherosclerosis study (IRAS). Circulation, 2000;102:42-47.

61. Manson JE, Buring HE, et al. Relation between a diet with a high
glycemic load and plasma concentrations of high-sensitivity C-
reactive protein in middle-aged women. American Journal of Clinical
Nutrition, 2002;75:492-498.

62. Simin Liu, M.D., Ph.D., found that women who ate large amounts of
high-glycemic (or diabetes promoting) carbohydrates, including
potatoes, breakfast cereals, white bread, muffins, and white rice,
had very high CRP levels. Harvard Medical Journal 2000 Oct 19; 343
(16): 1139 47.
63. Lau CS, Morley KD, Belch JJF. Effects of fish oil supplementation
on non-steroidal anti inflammatory drug requirement in patients with
mild rheumatoid arthritis - a double-blind placebo controlled study.
British Journal of Rheumatology, 1993;32:982-989.
64. Curtis CL, Hughes CE, Flannery CR, et al. n-3 fatty acids
specifically modulate catabolic factors involved in articular
cartilage degradation. Journal of Biological Chemistry, 2000;275:721
65. Zurier RB, Rossetti RG, Jacobson EW, et al. Gamma-linolenic acid
treatment of rheumatoid arthritis. A randomized, placebo-controlled
study. Arthritis & Rheumatism, 1996;11:1808 1817.

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