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Saturday, July 23, 2011

[AlternativeAnswers] *Ehrlichia and bone marrow cells: Could Ehrlichial infection explain the unsusp

 


*Ehrlichia and bone marrow cells: Could Ehrlichial infection explain the
unsuspected etiology of some diseases of the immune system?*

Kallick CA

Med Hypotheses 2011 06 11

A large group of diseases of unknown etiology, including leukemia,
systemic lupus erythematosus, myelodysplastic disease, multiple
sclerosis, amyotrophic lateral sclerosis, and rheumatoid arthritis, all
present with some elements of immune system disturbance. The
Ehrlichia/anaplasma (EA) are an obscure group of obligate parasitic
intracellular pathogens that excrete intracellularly a substance called
host transcriptional protein, which can alter transcription in cell
division. Infection with EA may lead to changes in transcription in
proliferating cells, such as those in the marrow, and alter the biology
of the products such as T and B cells. Normally 60% of B cells produced
in the marrow may be self reactive, but are eliminated before release
from the marrow. Changes in transcription could allow self reactive
cells to escape into the peripheral circulation and injure normal
tissue, creating the dysfunctions which characterize the different
immune system diseases and give t hem their separate identities. A
number of studies previously published, and new information presented
here, suggest that EA infections may be an underlying, undiagnosed cause
for these and other immune system diseases. This hypothesis, long
overlooked, has never been subjected to adequate, rigorous study
sufficient to prove or disprove its truth. If so, patients may be
treated with antibiotics, and marrow transplant manipulations already
used in treatment of diseases such as lupus and leukemia may become more
effective.

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