_http://www.liebertonline.com/doi/abs/10.1089/vbz.2010.0102_
(http://www.liebertonline.com/doi/abs/10.1089/vbz.2010.0102)
Vector-Borne and Zoonotic Diseases
Borreliosis During Pregnancy: A Risk for the Unborn Child?
To cite this article:
Ioannis Mylonas.
Vector-Borne and Zoonotic Diseases. July 2011, 11(7): 891-898.
doi:10.1089/vbz.2010.0102.
Published in Volume: 11 Issue 7: July 7, 2011
Online Ahead of Print: October 6, 2010
Abstract
Little is known regarding the possible harmful effects of Borrelia
infections in pregnancy, since such a risk analysis is difficult to
perform. Transplacental transmission of Borrelia burgdorferi has been
documented in several animal studies. Therefore, it had been thought
that fetal infection and teratogenicity was possible from B.
burgdorferi, especially considering the similarities between Lyme
borreliosis and syphilis. However, several clinical, serological, and
epidemiological studies have failed to confirm a causal association
between B. burgdorferi infection and a pregnancy adverse outcome.
Moreover, there have been no reported cases of transmission of Borrelia
via breast milk. However, the therapeutic approach to pregnant women
with Lyme disease should be antibiotic treatment, according to the
clinical manifestation and the timing of the tick bite. An effective
vaccine is not yet available and the prevention of Lyme borreliosis
depends on public and physician education, and appropriate antibiotic
therapy during pregnancy.
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