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Tuesday, March 1, 2011

[AlternativeAnswers] Transfusion-Transmitted Babesia spp.: Bull's-Eye on Babesia microti.

 


Clin Microbiol Rev. 2011 Jan;24(1):14-28.

Transfusion-Transmitted Babesia spp.: Bull's-Eye on Babesia microti.

Leiby DA.

Mailing address: Transmissible Diseases Department, American Red Cross
Holland Laboratory, 15601 Crabbs Branch Way, Rockville, MD 20855.
leibyd@usa.redcross.org.

Summary: Babesia spp. are intraerythrocytic protozoan parasites of animals
and humans that cause babesiosis, a zoonotic disease transmitted primarily
by tick vectors. Although a variety of species or types of Babesia have
been
described in the literature as causing infection in humans, the rodent
parasite Babesia microti has emerged as the focal point of human disease,
especially in the United States. Not only has B. microti become established
as a public health concern, this agent is increasingly being transmitted by
blood transfusion:
estimates suggest that between 70 and 100 cases of transfusion-transmitted
Babesia (TTB) have occurred over the last 30 years. A recent upsurge in TTB
cases attributable to B. microti, coupled with at least 12 fatalities in
transfusion recipients diagnosed with babesiosis, has elevated TTB to a key
policy issue in transfusion medicine. Despite clarity on a need to mitigate
transmission risk, few options are currently available to prevent the
transmission of B. microti by blood transfusion. Future mitigation efforts
may stress serological screening of blood donors in regionalized areas of
endemicity, with adjunct nucleic acid testing during the summer months,
when
acute infections are prevalent. However, several hurdles remain, including
the absence of a licensed blood screening assay and a thorough cost-benefit
analysis of proposed interventions. Despite current obstacles, continued
discussion of TTB without proactive intervention is no longer a viable
alternative.

http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=212
33506&retmode=ref&cmd=prlinks
PMID: 21233506 [PubMed - in process]

[Non-text portions of this message have been removed]

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