Neurol. 1989 Sep;236(6):322-8.
Meningoradiculitis and encephalomyelitis due to Borrelia burgdorferi: a
follow-up study of 72 patients over 27 years.
Krüger H, Reuss K, Pulz M, Rohrbach E, Pflughaupt KW, Martin R, Mertens HG.
Abstract
In 1987, follow-up studies were conducted on 72 patients who had had
meningoradiculitis and encephalomyelitis (8 patients) due to Borrelia
burgdorferi 5-27 years previously. These patients had not been treated with
antibiotics, either during the acute disease or during the interval prior to
follow-up studies. The patients had exhibited the typical symptoms of Bannwarth's
syndrome during the acute phase. At the follow-up studies, 33 patients
showed no, and 23 only mild, clinical residual symptoms including normal CSF
findings and low-positive serum IgG borrelia antibody titres (IFT; ELISA).
Three patients without sequelae exhibited persistent intrathecal secretion of
oligoclonal B. burgdorferi-specific CSF IgG antibodies (Immunoblot;
positive borrelia CSF IgG antibody titres). Thirteen patients exhibited
mild-to-medium sequelae with persistent intrathecal formation of oligoclonal B.
burgdorferi-specific CSF IgG antibodies, up to 21 years after the acute
illness. This persistence can be interpreted as an "immunological scar syndrome".
Our follow-up studies appear to indicate that neurological manifestations
of B. burgdorferi infections are generally (with few exceptions) of a benign
nature. Most patients can be classified as having been cured without
antibiotic therapy. No late manifestations of chronic progressive CNS
borreliosis comparable to that of neurosyphilis have been seen following acute
untreated neuroborreliosis.
PubMed: _http://www.ncbi.nlm.nih.gov/pubmed/2795099_ (http://
www.ncbi.nlm.nih.gov/pubmed/2795099)
These guys never got treated in spite of a close to guaranteed Lyme
infection. It is a bit fun to read the paper, since some of them obviously have
titers high enough to warrant the investigating med's to recommend an
antibiotic treatment....after 27 yrs. But these guys are like; Huh, why me I feel
just ok? While yet another guy who doesn't qualify for treatment on the
grounds of IgG still has to treat himself with corticostereoids for a chronic
licen ruber planus, which I personally willing bet >1€ is caused by
persistent Lyme. Dr G.
[Non-text portions of this message have been removed]
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